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Biological Chemistry II >> Content Detail



Calendar / Schedule



Calendar

The calendar lists both lecture (L#) and recitation (TD#) sessions. Recitations are referred to as the Techniques and Discussion (TD) sessions. See syllabus for a description of the modules.

SES #TOPICSKEY DATES
Module 1: Size and Components of Cells and Implications with respect to Regulation
L1Introduction: cell constituents, prokaryotes vs. eukaryotes
L2Introduction (cont.)
Module 2: Fatty Acid Synthases (FAS), Polyketide Synthases (PKS), and Non-ribosomal Polypeptide Synthases (NRPS)
L3Fatty Acid Synthase: polymerization, biosynthesis, players, chemistry, structure, chemistry as a paradigm for PKS and NRPS, medical interlude
L4Experimental methods for elucidating FAS structure
TD1Beta-ketoacyl-ACP Synthase I (FabB)
L5Chemistry of FAS as paradigm for other molecular machines
L6Secondary metabolism: PKS, NRPS
L7Chemistry of PKS and NRPS: post-translational modification, initiation, elongation, decoration, termination, fidelityProblem set 1 due
TD2Smith Paper
L8Chemistry of PKS and NRPS (cont.)
L9Chemistry of PKS and NRPS (cont. with specific examples)Problem set 2 due
L10Biosynthesis of yersiniabactin and cholesterolExam 1
TD3Walsh Paper
L11Cholesterol biosynthesis
L12Cholesterol regulation and homeostasis
L13Sensing insoluble molecules
TD4Endocytosis of LDL and Radioactivity Techniques
L14Module 2: Regulation of the transcription level by insoluble metabolites and Module 3: Translation
Module 3: Translation: Loading, Initiation, Elongation, and Termination - A Machine in Action; Introduction to G-proteins: Switches or Motors
L15Translation (cont.)Problem set 3 due
L16Elongation, termination, RNA polymerase
TD5Structure
L17Chemical methods for studying translation and the ribosome
L18Chemical methods for studying translation and the ribosome (cont.)
L19Chemical methods for studying translation and the ribosome (cont.)Problem set 4 due
TD6Hydroxyl Radical FootprintingExam 2
L20Isoleucine tRNA synthetase
TD7Gel Electrophoresis; Photoaffinity Probes
L21tRNA synthase editing mechanisms; G proteins (EF-Tu/EF-G)
L22G proteins: motors
TD8Rodnina Paper
L23G proteins: switches
L24Peptide bond formation; new technologies using the ribosomeProblem set 5 due
L25Module 3: methods for the incorporation of unnatural amino acids and Module 4: what happens as a protein exits the ribosome?Exam 3
Module 4: Crypts and Chambers: Macromolecular Machines involved in Protein Folding and Degradation
TD9FRET, Steady State
L26Protein folding in vitro
TD10Exam 3 Answers and Discussion
L27Protein folding: in vitro vs. in vivo; degradation
L28Protein folding in vivo
L29Chaperone proteins
TD11GroEl / GroES
L30GroEL/GroES
L31ProteasesProblem set 6 due
L32ProteosomeExam 4
TD12DnaJ specificity
L33Proteosome (cont.)
L34Role of Ubiquitin in degradation
L35Degradation through polyubiquitination
Final Exam (3 hours. The first 30 minutes will cover the information since the last exam. The remaining two and a half hours will cover the entire semester.)

 








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