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Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer >> Content Detail



Study Materials



Readings

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SES #TOPICSreadings
1Introduction
2The Cell Cycle

Evans, T., E. T. Rosenthal, J. Youngblom, D. Distel, and T. Hunt. "Cyclin: A Protein Specified by Maternal mRNA in Sea Urchin Eggs that Is Destroyed at each Cleavage Division." Cell 33, no. 2 (1983): 389-396. (PDF)#

Shirodkar, S., M. Ewen, J. A. DeCaprio, J. Morgan, D. M. Livingston, and T. Chittenden. "The Transcription Factor E2F Interacts with the Retinoblastoma Product and a p107-Cyclin A Complex in a Cell Cycle-Regulated Manner." Cell 68, no. 1 (1992): 157-166.

3G1 Phase and Initiation of DNA Replication

Donovan, S., J. Harwood, L. S. Drury, and J. F. Diffley. "Cdc6p-Dependent Loading of Mcm Proteins onto Pre-Replicative Chromatin in Budding Yeast." Proceedings of the National Academy of Sciences of the United States of America 94, no. 11 (1997): 5611-5616. (PDF)#

Mailand, N., and J. F. Diffley. "CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis." Cell 122, no. 6 (2005): 915-926. (PDF)#

4S Phase and Replication Fork Regression

Dimitrova, D. S., and D. M. Gilbert. "The Spatial Position and Replication Timing of Chromosomal Domains Are both Established in Early G1 Phase." Molecular Cell 4, no. 6 (1999): 983-993. (PDF)#

Moyer, S. E., P. W. Lewis, and M. R. Botchan. "Isolation of the Cdc45/Mcm2-7/GINS (CMG) Complex, a Candidate for the Eukaryotic DNA Replication Fork Helicase." Proceedings of the National Academy of Sciences of the United States of America 103, no. 27 (2006): 10236-10241. (PDF - 1.7 MB)#

5Cell Cycle Control of DNA Replication

Hayles, J., D. Fisher, A. Woollard, and P. Nurse. "Temporal Order of S Phase and Mitosis in Fission Yeast Is Determined by the State of the p34cdc2 Mitotic B Cyclin Complex." Cell 78, no. 5 (1994): 813-822.

Nguyen, V. Q., C. Co, and J. J. Li. "Cyclin-Dependent Kinases Prevent DNA Re-Replication through Multiple Mechanisms." Nature 411, no. 6841 (2001): 1068-1073. (PDF)#

6Checkpoints

Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan. "Wild-Type p53 Is a Cell Cycle Checkpoint Determinant Following Irradiation." Proceedings of the National Academy of Sciences of the United States of America 89, no. 16 (1992): 7491-7495. (PDF - 1.5 MB)#

Katou, Y., Y. Kanoh, M. Bando, H. Noguchi, H. Tanaka, T. Ashikari, K.Sugimoto, and K. Shirahige. "S-Phase Checkpoint Proteins Tof1 and Mrc1 Form a Stable Replication-Pausing Complex." Nature 424, no. 6952 (2003): 1078-1083.

7DNA Repair

Bienko, M., C. M. Green, N. Crosetto, F. Rudolf, G. Zapart, B. Coull, and P. Kannouche, et al. "Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis." Science 310, no. 5755 (2005): 1821-1824.

Spagnolo, L., A. Rivera-Calzada, L. H. Pearl, and O. Llorca. "Three Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and its Implications for DNA DSB Repair." Molecular Cell 22, no. 4 (2006): 511-519.

8Midterm Assignments
9Development and Endoreduplication

Verkest, A., C. L. Manes, S. Vercruysse, S. Maes, E. Van Der Schueren, T. Beeckman, P. Genschik, M. Kuiper, D. Inze, and L. De Veylder. "The Cyclin-Dependent Kinase Inhibitor KRP2 Controls the Onset of the Endoreduplication Cycle during Arabidopsis Leaf Development through Inhibition of Mitotic CDKA; 1 Kinase Complexes." The Plant Cell 17, no. 6 (2005): 1723-1736. (PDF)#

Gregoire, D., K. Brodolin, and M. Mechali. "HoxB Domain Induction Silences DNA Replication Origins in the Locus and Specifies a Single Origin at its Boundary." EMBO Reports 7, no. 8 (2006): 812-816.

10Recombination and Meiosis

Borde, V., A. S. Goldman, and M. Lichten. "Direct Coupling between Meiotic DNA Replication and Recombination Initiation." Science 290, no. 5492 (2000): 806-809.

Bhalla, N., and A. F. Dernburg. "A Conserved Checkpoint Monitors Meiotic Chromosome Synapsis in Caenorhabditis Elegans." Science 310, no. 5754 (2005): 1683-1686.

11DNA Replication and Cancer

Tanaka, S. and J. F. Diffley. "Deregulated G1-Cyclin Expression Induces Genomic Instability by Preventing Efficient Pre-RC Formation." Genes & Development 16, no. 20 (2002): 2639-2649.

Honeycutt, K. A., Z. Chen, M. I. Koster, M. Miers, J. Nuchtern, J. Hicks, D. R. Roop, and J. M. Shohet. "Deregulated Minichromosomal Maintenance Protein MCM7 Contributes to Oncogene Driven Tumorigenesis." Oncogene 25, no. 29 (2006): 4027-4032.

12Targeting Replication Components as Chemotherapy

Li, J. L., Y. C. Cai, X. H. Liu, and L. J. Xian. "Norcantharidin Inhibits DNA Replication and Induces Apoptosis with the Cleavage of Initiation Protein Cdc6 in HL-60 Cells." Anti-Cancer Drugs 17, no. 3 (2006): 307-314.

Cantero, G., N. Pastor, S. Mateos, C. Campanella, and F. Cortes. "Cisplatin-Induced Endoreduplication in CHO Cells: DNA Damage and Inhibition of Topoisomerase II." Mutation Research 599, no. 1-2 (2006): 160-166.

13Viral Reprogramming of the Cell Cycle

Yew, P. R. and A. J. Berk. "Inhibition of p53 Transactivation Required for Transformation by Adenovirus Early 1B Protein." Nature 357, no. 6373 (1992): 82-85.

Wiebusch, L., R. Uecker, and C. Hagemeier. "Human Cytomegalovirus Prevents Replication Licensing by Inhibiting MCM Loading Onto Chromatin." EMBO Reports 4, no. 1 (2003): 42-46. (PDF)#

14Final Assignments Presented

 








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