Neuron-glial Cell Interactions in Biology and Disease >> Content Detail

Study Materials


1Overview of the class, introduction to glia and use of pubmed

Barres, B. A. "What is a Glial Cell?Glia 43, no. 1 (July 2003): 4-5.

Somjen, G. G. "Nervenkitt: Notes on the History of the Concept of Neuroglia." Glia 1, no. 1 (1988): 2-9.

2Myelination in the peripheral nervous system (PNS): Schwann cells

Eshed, Y., K. Feinberg, S. Poliak, H. Sabanay, O. Sarig-Nadir, I. Spiegel, J. R. Jr. Bermingham, and E. Peles. "Gliomedin Mediates Schwann Cell-axon Interaction and the Molecular Assembly of the Nodes of Ranvier." Neuron 47, no. 2 (July 21, 2005): 215-29.

Oh, S., Y. Ri, M. V. Bennett, E. B. Trexler, V. K. Verselis, T. A. Bargiello. "Changes in Permeability Caused by Connexin 32 Mutations Underlie X-linked Charcot-Marie-Tooth Disease." Neuron 19, no. 4 (October 1997): 927-38.

3Myelination in the central nervous system (CNS): Oligodendrocytes

Kaplan, M. R., M. H. Cho, E. M. Ullian, L. L. Isom, S. R. Levinson, and B. A. Barres. "Differential Control of Clustering of the Sodium Channels Na(v)1.2 and Na(v)1.6 at Developing CNS Nodes of Ranvier." Neuron 30, no. 1 (April 2001): 105-19.

Craner, M. J., J. Newcombe, J. A. Black, C. Hartle, M. L. Cuzner, and S. G. Waxman. "Molecular Changes in Neurons in Multiple Sclerosis: Altered Axonal Expression of Nav1.2 and Nav1.6 Sodium Channels and Na+/Ca2+ Exchanger." Proc Natl Acad Sci U.S.A. 101, no. 21 (May 25, 2004): 8168-73.

4The Nogo hypothesis

Zheng, B., C. Ho, S. Li, H. Keirstead, O. Steward, and M. Tessier-Lavigne. "Lack of Enhanced Spinal Regeneration in Nogo-deficient Mice." Neuron 38, no. 2 (April 24, 2003): 213-24.

Karnezis, T., W. Mandemakers, J. L. McQualter, B. Zheng, P. P. Ho, K. A. Jordan, B. M. Murray, B. Barres, M. Tessier-Lavigne, and C. C. Bernard. "The Neurite Outgrowth Inhibitor Nogo A is Involved in Autoimmune-mediated Demyelination." Nat Neurosci 7, no. 7 (July 2004): 736-44.

5Neuregulin-1 and schizophrenia

Michailov, G. V., M. W. Sereda, B. G. Brinkman, T. M. Fischer, B. Haug, C. Birchmeier, L. Role, C. Lai, M. H. Schwab, and K. A. Nave. "Axonal Neuregulin-1 Regulates Myelin Sheath Thickness." Science 30, no. 5671 (April 30, 2004): 700-3.

Hahn, C. G., H. Y. Wang, D. S. Cho, K. Talbot, R. E. Gur, W. H. Berrettini, K. Bakshi, J. Kamins, K. E. Borgmann-Winter, S. J. Siegel, R. J. Gallop, and S. E. Arnold. "Altered Neuregulin 1-erbB4 Signaling Contributes to NMDA Receptor Hypofunction in Schizophrenia." Nat Med 12, no. 7 (July 2006): 824-8.

6Field tripRoy, Kristine, Dr. "Loss of erbB Signaling in Oligodendrocytes Alters Myelin and Dopaminergic Function, a Potential Mechanism for Neuropsychiatric Disorders." Proc Natl Acad Sci U S A 104, no. 19 (May 8, 2007): 8131-6.
7CNS Astrocytes, part I: Interactions with oligodendrocytes

Ishibashi, T., K. A. Dakin, B. Stevens, P. R. Lee, S. V. Kozlov, C. L. Stewart, and R. D. Fields. "Astrocytes Promote Myelination in Response to Electrical Impulses." Neuron 49, no. 6 (March 16, 2006): 823-32.

Antony, J. M., G. van Marle, W. Opii, D. A. Butterfield, F. Mallet, V. W. Yong, J. L. Wallace, R. M. Deacon, K. Warren, and C. Power. "Human Endogenous Retrovirus Glycoprotein-mediated Induction of Redox Reactants Causes Oligodendrocyte Death and Demyelination ." Nat Neurosci 7, no. 10 (October 2004): 1088-95.

8CNS Astrocytes, part II: Neuromodulation and Alzheimer's disease

Beattie, E. C., D. Stellwagen, W. Morishita, J. C. Bresnahan, B. K. Ha, M. Von Zastrow, M. S. Beattie, and R. C. Malenka. "Control of Synaptic Strength by Glial TNFalpha." Science 295, no. 5563 (March 22, 2002): 2282-5.

Rossi, D., L. Brambilla, C. F. Valori, A. Crugnola, G. Giaccone, R. Capobianco, M. Mangieri, A. E. Kingston, A. Bloc, P. Bezzi, and A. Volterra. "Defective Tumor Necrosis Factor-alpha-dependent Control of Astrocyte Glutamate Release in a Transgenic Mouse Model of Alzheimer Disease." J Biol Chem 280, no. 51 (December 23, 2005): 42088-96.

9CNS Astrocytes, part III: Synaptogenesis and epilepsy

Ullian, E. M., S. K. Sapperstein, K. S. Christopherson, and B. A. Barres. "Control of Synapse Number by Glia." Science 291, no. 5504 (January 26, 2001): 657-61.

Tian, G. F., H. Azmi, T. Takano, Q. Xu, W. Peng, J. Lin, N. Oberheim, N. Lou, X. Wang, H. R. Zielke, J. Kang, and M. Nedergaard. "An Astrocytic Basis of Epilepsy." Nat Med 11, no. 9 (September 2005): 973-81.

10CNS Astrocytes, part IV: The role of glial cells in adult neurogenesis

Doetsch, F., I. Caille, D. A. Lim, J. M. Garcia-Verdugo, and A. Alvarez-Buylla. "Subventricular Zone Astrocytes are Neural Stem Cells in the Adult Mammalian Brain." Cell 97, no. 6 (June 11, 1999): 703-16.

Song, H., C. F. Stevens, and F. H. Gage. "Astroglia Induce Neurogenesis from Adult Neural Stem Cells." Nature 417, no. 6884 (May 2, 2002): 39-44.

11CNS Astrocytes, part V: Gliomas

Takano, T., J. H. Lin, G. Arcuino, Q. Gao, J. Yang, and M. Nedergaard. "Glutamate Release Promotes Growth of Malignant Gliomas." Nat Med 7, no. 9 (September 2001): 1010-5.

Piccirillo, S. G., B. A. Reynolds, N. Zanetti, G. Lamorte, E. Binda, G. Broggi, H. Brem, A. Olivi, F. Dimeco, and A. L. Vescovi. "Bone Morphogenetic Proteins Inhibit the Tumorigenic Potential of Human Brain Tumour-initiating Cells." Nature 444, no. 7120 (December 7, 2006): 761-5.

12Microglia of the CNS

Bezzi, P., M. Domercq, L. Brambilla, R. Galli, D. Schols, E. De Clercq, A. Vescovi, G. Bagetta, G. Kollias, J. Meldolesi, and A. Volterra. "CXCR4-activated Astrocyte Glutamate Release via TNFalpha: Amplification by Microglia Triggers Neurotoxicity." Nat Neurosci 4, no. 7 (July 2001): 702-10.

Hains, B. C., and S. G. Waxman. "Activated Microglia Contribute to the Maintenance of Chronic Pain After Spinal Cord Injury." J Neurosci 26, no. 16 (April 19, 2006): 4308-17.

132nd assignment: Oral presentations


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