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Course Info

  • Course Number / Code:
  • 7.344 (Fall 2004) 
  • Course Title:
  • RNA Interference: A New Tool for Genetic Analysis and Therapeutics 
  • Course Level:
  • Undergraduate 
  • Offered by :
  • Massachusetts Institute of Technology (MIT)
    Massachusetts, United States  
  • Department:
  • Biology 
  • Course Instructor(s):
  • Dr. Stephan Kissler
    Dr. Andrea Ventura 
  • Course Introduction:
  •  


  • 7.344 RNA Interference: A New Tool for Genetic Analysis and Therapeutics



    Fall 2004




    Course Highlights


    This course features a full bibliography in the readings section.


    Course Description


    This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.

    To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has already changed the way biomedical research is done and that may even prove useful for genetic interventions in a clinical context. In this course, students learn how RNAi was discovered, how it works, and what its physiological relevance might be. How RNAi can be harnessed to modulate gene expression and perform genetic screens, both in cells and in various organisms is also covered. Finally, this course examines the first attempts to use RNAi for the treatment of models of human diseases in experimental animals.

     

ACKNOWLEDGEMENT:
This course content is a redistribution of MIT Open Courses. Access to the course materials is free to all users.






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