Biological and Biomedical Sciences >> Systems Biology

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Course Info

  • Course Number / Code:
  • 7.91J (Spring 2004) 
  • Course Title:
  • Foundations of Computational and Systems Biology 
  • Course Level:
  • Undergraduate / Graduate 
  • Offered by :
  • Massachusetts Institute of Technology (MIT)
    Massachusetts, United States  
  • Department:
  • Biology 
  • Course Instructor(s):
  • Prof. Christopher Burge
    Prof. Amy Keating
    Prof. Michael Yaffe
    Dr. Peter Woolf  
  • Course Introduction:

  • 7.91J / 7.36J / 20.490J Foundations of Computational and Systems Biology

    Spring 2004

    Course Highlights

    The MIT Initiative in Computational and Systems Biology (CSBi) is a campus-wide research and education program that links biology, engineering, and computer science in a multidisciplinary approach to the systematic analysis and modeling of complex biological phenomena. This course is one of a series of core subjects offered through the CSB Ph.D program, for students with an interest in interdisciplinary training and research in the area of computational and systems biology.

    This course site includes an extensive listing of bioinformatics tools with links to online resources in the tools section as well as a full set of lecture notes.

    Course Description

    Serving as an introduction to computational biology, this course emphasizes the fundamentals of nucleic acid and protein sequence analysis, structural analysis, and the analysis of complex biological systems. The principles and methods used for sequence alignment, motif finding, structural modeling, structure prediction, and network modeling are covered. Students are also exposed to currently emerging research areas in the fields of computational and systems biology.

    Technical Requirements

    MATLAB® software is required to run the .m files found on this course site. RasMol software or another molecular graphics program (e.g. DeepView, PyMol) is required to view the .pdb files found on this course site. Any number of biological sequence comparison software tools can be used to import the FASTA formatted sequence (.fa) files found on this course site. Use the Python Interpreter to run the .py files found on this course site. Media player software, such as QuickTime® PlayerRealOne™ Player, or Windows Media® Player, is required to run the .avi files found on this course site.

    *Some translations represent previous versions of courses.


This course content is a redistribution of MIT Open Courses. Access to the course materials is free to all users.

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