Biomaterials-Tissue Interactions (BE.441) >> Content Detail

Study Materials


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Amazon logo Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.

I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes
L1Survey of Clinical Cases of Biomaterials-Tissue InteractionsSurvey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm (PDF)
L2Tissue Structures, Unit Cell Processes, and IntegrinsGiancotti, F. G., and E. Ruoslahti. "Integrin Signaling." Science 285 (13 Aug 1999): 1028-1032.
This paper presents the concept of integrin signaling.

Ruoslathi, E., and M. D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (23 Oct 1987): 491-497.
This paper describes the discovery of an amino acid sequence that is a ligand for integrins.

Working/Operational Definitions (PDF)

Tissue Structure/Unit Cell Processes (PDF)
L3Unit Cell Processes Comprising the Healing Response
L4Irreversible Healing Behavior of the Extracellular Matrix (ECM) of OrgansChapters 1-4
L5Biochemistry of the ECMExtracellular Matrix Molecules (PDF)
L6Scaffolds Based on ECM Analogs Used in Organ SynthesisChapter 8
L7Organ Replacement by Induced Regeneration and Tissue Engineering
L8Principles and Practice of Tissue Engineering
E1Quiz 1
II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue
L9Characteristics of the Surfaces of BiomaterialsCharacteristics of the Surfaces of Biomaterials (PDF)
L10Methodology for the Analysis of SurfacesAmazon logo Ratner, B. D. "Surface Properties of Biomaterials." In Biomaterials Science. Edited by B. D. Ratner, et. al. Burlington, MA: Academic Press, 1996. ISBN: 9780125824606.

Methodology for Chemical Analysis of Surfaces (PDF)
L11Physicochemical Principles of Protein Adsorption on Solid SurfacesAndrade, J. D. "Principles of Protein Adsorption." In Surface and Interfacial Aspects of Biomedical Polymers. Vol. 2. Edited by J. D. Andrade. NY: Plenum Press, 1985.

Chinn, J. A., et. al. "Postadsorptive transitions in fibrinogen adsorbed to polyurethanes." Journal of Biomedical Materials Research 26 (1992): 757-778.

Rapoza, R. J., and T. A. Horbett. "Postadsorptive transitions in fibrinogen: Influence of polymer properties." Journal of Biomedical Materials Research 24 (1990): 1263-1287.
L12Protein/Cell/Tissue-Biomaterials Interactions
L13Linear vs. Cooperative Cell-Matrix Interactions
L14Cell-Matrix Interactions During Spontaneous HealingChapter 9
L15Contraction-Blocking Theory of Regeneration in AdultsChapters 8 and 10
E2Quiz 2
III. In Vivo and Clinical Case Studies
L16Joints and Dental Tissues: Prosthetic ReplacementJoints: Regeneration of Bone, Cartilage, Meniscus, Ligament, and Tendon (PDF)
L17Joints and Dental Tissues: Regeneration 1
L18Joints and Dental Tissues: Regeneration 2
L19Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses
L20Rules for Synthesis of Tissues and OrgansChapter 7
L21In Vivo Synthesis of SkinChapter 5
L22In Vivo Synthesis of Peripheral NervesChapter 6
L23In Vivo Synthesis of the Conjunctiva and of Kidney TissueChapter 8
E3Quiz 3


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