Protein Folding Problem >> Content Detail

Lecture Notes

Lecture Notes

The lecture notes linked below are from the Fall 2003 version of this course. The lecture notes were created by Prof. King unless otherwise noted.

1Introduction to the problem(PDF)

Side-chain review

Sulfur redox chemistry

3The Anfinsen experiments(PDF)

Globular protein structure

Protein interiors

5Using the Protein database (PDB)(PDF - 2.5 MB) (Courtesy of Prof. David Gossard)
6Helix-helix packing in globular proteins(PDF)


Beta-sheet packing

8Experimental techniques: circular dichroism

Thermal denaturation

Coiled coils

Refolding of tropomyosin

(PDF 1) (Courtesy of Prof. David Gossard)

(PDF 2)

10Fluorescence spectroscopy
11S-peptide helical folding(PDF)
12Detecting partially folded intermediates(PDF)
13Prolyl isomerization
14Cytochrome c refolding pathway(PDF)
152-D NMR techniques
16Collagen structure and folding in vivo(PDF - 1.8 MB) (Courtesy of Prof. David Gossard)
17Procollagen folding in vitro
18Protein calorimetry: BPTI
19Protein misfolding and aggregation(PDF)

Ribosome channel

Nascent chains

Trigger factor

21Scaffolding proteins in viral shell assembly
22Amyloid fiber formation in neuro degenerative disease
24Chaperonin assisted folding(PDF)
25Eukariotic chaperonins
26Paper topic discussion and choices
27Membrane protein (rhodopsin) folding and assembly
28Prion diseases
29Etiology of some human protein deposition diseases


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