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Protein Folding Problem >> Content Detail



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SES #TOPICSKEY DATES
1Introduction to the problemAssignment 1 out
2

Side-chain review

Sulfur redox chemistry

3The Anfinsen experimentsAssignment 2 out
4

Globular protein structure

Protein interiors

5Using the Protein Database (PDB)Assignment 3 out
6Helix-helix packing in globular proteins
7

Beta-sheets

Beta-sheet packing

8Experimental techniques: circular dichroismAssignment 4 out
9

Thermal denaturation

Coiled coils

Refolding of Tropomyosin

10Fluorescence spectroscopyAssignment 5 out
11S-peptide helical folding
12Detecting partially folded intermediates
13Prolyl isomerizationAssignment 6 out
14Cytochrome c refolding pathway
152-D NMR techniquesAssignment 7 out
16Collagen structure and folding in vivo
17Procollagen folding in vitro
18Protein calorimetry: BPTI
19Protein misfolding and aggregation
20

Ribosome channel

Nascent chains

Trigger factor

Graded problem set due
21Scaffolding proteins in viral shell assembly
22Amyloid fiber formation in neuro degenerative disease
23Mid-term exam
24Chaperonin assisted folding
25Eukariotic chaperonins
26Paper topic discussion and choices
27Membrane protein (rhodopsin) folding and assembly
28Prion diseases
29Etiology of some human protein deposition diseases
30-37Student presentations
38Final papers due

 








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