Cell-Matrix Mechanics >> Content Detail



Amazon logo Help support MIT OpenCourseWare by shopping at! MIT OpenCourseWare offers direct links to to purchase the books cited in this course. Click on the Amazon logo to the left of any citation and purchase the book from, and MIT OpenCourseWare will receive up to 10% of all purchases you make. Your support will enable MIT to continue offering open access to MIT courses.

Course Topics

  • Response of cells and tissues to exogenous mechanical loading.
  • Endogenous mechanical forces generated by cells (viz., contractile forces generated by connective tissue cells).
  • Molecular structure-mechanical properties relationships for selected connective tissues.
    • Chemical composition of the extracellular matrix of tissues.
    • Structure of tissues (viz., connective tissues) at the nanometer, micrometer, and millimeter length scales (including the hierarchical structure of tissues).
    • Load-deformation behavior of tissues at the micrometer and millimeter scales.

  • Interrelationships among the above.

Unique Aspects of the Subject

  • Assessment of the response of cells and tissues to mechanical forces; discussion of mechano-transduction mechanisms.
  • Discussion of contraction of connective tissue cells.

Course Textbook

Amazon logo Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.

This book is supplemented by papers, presentations and readings.


The course grade is based entirely on the three quizzes.


© 2009-2020, All Rights Reserved.
Higher Ed Space ® is a registered trademark of AmeriCareers LLC.