Cell-Matrix Mechanics >> Content Detail

Study Materials


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Yannas readings are chapters in the course textbook: Amazon logo Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.

I. Unit Cell Processes and Mechanics of Matrix Molecules and Tissues Structures
1Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working ParadigmsSpector notes (PDF)
2Tissue Structures and Unit Cell ProcessesSpector notes (PDF)
3Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and IntegrinsSpector notes (PDF 1) (PDF 2)

Stossel, Thomas P. "On the Crawling of Animal Cells." Science, New Series, 260, no. 5111 (May 21, 1993): 1086-1094.

Hinz, Boris, Giuseppe Celetta, James J. Tomasek, Giulio Gabbiani, and Christine Chaponnier. "Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity." Molecular Biology of the Cell 12 (September 2001): 2730-2741.

Vale, Ronald D., and Ronald A. Milligan. "The Way Things Move: Looking Under the Hood of Molecular Motor Proteins." Science 288 (April 7, 2000).
4Models for the Mechanical Behavior of Porous Scaffolds
5Structure-Properties Relationships for Tissues
6Mechanics of Selected Tissues
II. Mechanics of Cells: Effects of Exogenous Forces and Endogenous Force Generation
7Effects of Exogenous Mechanical Forces on CellsSpector notes (PDF)
8Response of Cells to Substrate StrainBanes, Albert J., Mari Tsuzaki, Juro Yamamoto, Thomas Fischer, Brian Brigman, Thomas Brown, and Larry Miller. "Mechanoreception at the Cellular Level: The Detection, Interpretation, and Diversity of Responses to Mechanical Signals." Biochem Cell Biol 73 (1995): 349-365.

Davies, Peter F., and Satish C. Tripathi. "Mechanical Stress Mechanisms and the Cell - An Endothelial Paradigm." Circulation Research 72, no. 2 (February, 1993): 239-245.

Wang, Ning, James P. Butler, and Donald E. Ingber. "Mechanotransduction Across the Cell Surface and Through the Cytoskeleton." Science, New Series, 260, no. 5111 (May 21, 1993): 1124-1127.

Alenghat, Francis J., and Donald E. Ingber. "Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins." Sciences, STKE (Feb 12, 2002).

Schaffer, Jonathan L., Michael Rizen, Gilbert J. L'Italien, Aziz Benbrahim, Joseph Megerman, Louis C. Gerstenfeld, and Martha L. Gray. "Device for the Application of a Dynamic Biaxially Uniform and Isotropic Strain to a Flexible Cell Culture Membrane." Journal of OrthoPaedic Research 12: 709-719.

McNeil, Paul L., and Richard A. Steinhardt. "Loss, Restoration, and Maintenance of Plasma Membrane Integrity." The Journal of Cell Biology 137, no. 1 (April 7, 1997): 1-4.

McNeil, Paul L., and Richard A. Steinhardt. "Plasma Membrane Disruption: Repair, Prevention, Adaptation." Annu Rev. Cell Dev. Biol. 19 (July 8, 2003): 697-731.

Miyake, Katsuya, and Paul L. McNeil. "Mechanical Injury and Repair of Cells." Crit Care Med 31, no. 8 (Suppl. 2003).
9Endothelial Cell Response to Flow
10Quiz 1
11Measuring Cell Contraction

Cell Force Monitor
12Endogenous Mechanical Force Generation by Cells
13Models for Cell Contraction In Vitro and In Vivo
14Mechanical Coupling of Cells with MatrixYannas, Chapter 8.
15Cell-matrix Interactions During Wound ClosureYannas, Chapter 9.
16Blockade of Contraction During Induced Organ RegenerationYannas, Chapter 9.
17ReviewOliver, Tim, Juliet Lee, and Ken Jacobson. "Forces Exerted by Locomoting Cells." Cell Biology 5 (1994): 139-147.

Rutherford, Dr. Jack. "Structure and Function of Skeletal Muscle."

Wu, Richard C. "Physiology of smooth muscle."
18Quiz 2
III. Tissue Mechanics
19Review of Principles of Linear Elastic MechanicsYannas, Chapter 10.
20Nonlinear Elasticity: Tendon and SkinYannas, Chapter 11.
21Linear Viscoelastic BehaviorYannas, Chapter 9.
22Response of Articular Cartilage to Mechanical Loading
23Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc
24Mechanical Behavior of Bone
25Response of Bone to Mechanical Loading

26Quiz 3


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