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Fields, Forces, and Flows in Biological Systems (BE.430J) >> Content Detail



Study Materials



Readings

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The course textbook by Prof. Grodzinsky (Fields, Forces and Flows in Biological Systems) was provided to students as an unpublished manuscript.

References to "Deen" below are from the text: Amazon logo Deen, W. M. Analysis of Transport Phenomena. New York, NY: Oxford University Press, 1998. ISBN: 9780195084948.


ses #TOPICSreadings
L1Introduction/Summary

Examples
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."

Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix.
I. Chemical Subsystem
L2Continuity of Chemical Species, Flux, Reaction Rates, Boundary ConditionsGrodzinsky. Chapter 2, "Membrane Transport Phenomena."

Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix.
L3Diffusion

Begin Reaction

Damkohler #

Scaling and Approximations
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."

Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix.
L4Example Problems: Separation of Variables MethodGrodzinsky. Chapter 2, "Membrane Transport Phenomena."

Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix.
L5Example Problems: Separation of Variables Method (cont.)

Case Study: IGF Problem from Lecture L1 using Matrix Continuum Distribution of IGF Binding Proteins

Numerical Considerations (if time)
Grodzinsky. Chapter 2, "Membrane Transport Phenomena."

Deen 1.2, 1.4, 1.6, 2.2, 2.4, 2.6, 2.7, 2.8, 3.2, 3.3, 3.4, and Appendix.
III. Cellular Applications
L14Experimental MethodsPaper for discussion: Graff, C., and D. Wittrup. "Theoretical Analysis of Antibody Targeting of Tumor Spheroids: Importance of Dosage for Penetration, and Affinity for Retention." Cancer Res 2003.
L15Ligand Binding to Cell ReceptorsPaper for discussion: Haugh, et. al. "Spatial Sensing in Fibroblasts Mediated by 3' Phosphoinositides." J Cell Biol. 151, no. 6 (2000): 1269.

———. "Online Supplemental Material." J. Cell Biol. 151, no. 6 (2000).

 








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